Pharma Cogenetics

  • P139H - Human MTHFR MTRR Gene Polymorphism Detection Kit

    P139H - Human MTHFR MTRR Gene Polymorphism Detection Kit

    This kit is a supplementary reagent for the "Human MTHFR Gene Polymorphism Detection Kit", which can qualitatively detect the polymorphism of human MTHFR gene locus c.1298 and human MTRR gene locus c.66. Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the methionine-folate metabolism system,Together with MTRR, and maintains the normal metabolism of folic acid with methionine synthase  reductase(MTRR). In addition, it is also involved in maintaining normal homocysteine levels in the body. MTHFR and MTRR gene encode the key enzymes of folate metabolism and the mutations can reduce the activity of these enzymes, cause folate metabolism disorders, low folate levels and hyperhomocysteinemia. People with abnormal MTHFR gene has low enzyme activity and folic acid metabolism disorders, which lead to a  significantly increased risk of neonatal neural tube defects, Down syndrome, and cleft lip and palate. And such people need more folic acid supplements to achieve the desired effect.

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